Premier League leaders Liverpool will play at either Championship Bristol City or League One side Shrewsbury in the fourth round of the FA Cup.
Holders Manchester City face Fulham, while Chelsea also play second-tier opponents, away at Hull City.
Leicester, second in the Premier League, meet Championship Brentford.
The winners of the Manchester United v Wolves replay will play either Watford or Tranmere Rovers, with those sides also needing a replay after a 3-3 draw.
The matches will be played between Friday 24 and Monday 27 January.
Sixteen Premier League teams remain in the competition, while Northampton Town, ninth in League Two, are the lowest-ranked side who will definitely be playing in the last 32 and they are at home to Derby County.
Carlisle United, 21st in League Two, are the only other side from the fourth tier left in the tournament, although they face a third-round replay at home against Championship side Cardiff City. The winners of that game take on either Reading or Blackpool.
FA Cup fourth round draw
Watford or Tranmere Rovers v Wolverhampton Wanderers or Manchester United
Hull City v Chelsea
Southampton v Middlesbrough or Tottenham Hotspur
Queens Park Rangers v Sheffield Wednesday
Bournemouth v Arsenal or Leeds United
Northampton Town v Derby County
Brentford v Leicester City
Millwall v Sheffield United
Reading or Blackpool v Cardiff City or Carlisle United
West Ham United v West Bromwich Albion
Burnley v Norwich City
Bristol Rovers or Coventry City v Birmingham City
Manchester City v Fulham
Rochdale or Newcastle United v Oxford United
Portsmouth v Barnsley
Bristol City or Shrewsbury Town v Liverpool