Manchester City midfielder Kevin de Bruyne went off injured during their Premier League game against Tottenham.
The champions were leading 1-0 when the Belgian was replaced on 38 minutes with an apparent injury to his left knee.
He sat out two months at the start of the season because of a right knee problem before hurting his left knee in November and missing six weeks.
City, who play Manchester United on Wednesday, went into Saturday’s game two points behind leaders Liverpool.
Since returning to action in December, De Bruyne has been a key part of City’s title defence, making 15 league appearances.
Pep Guardiola’s side have four league games left after Saturday’s match at Etihad Stadium, as well as the FA Cup final against Watford.
Liverpool also have four league matches left, starting with a trip to relegation-threatened Cardiff City on Sunday.