Inter go head-to-head with Borussia Dortmund, relying on Romelu Lukaku and Lautaro Martinez, while Marco Reus is not fit to start.
It kicks off at the Signal Iduna Park at 20.00 GMT.
You can follow all the build-up and action as it happens from that game and Napoli-RB Salzburgon the LIVEBLOG.
Both sides go into this clash with four points in Group F, so it is essentially a duel to see who follows Barcelona into the Champions League Round of 16.
Inter won 2-0 at San Siro and the head-to-head record could prove decisive for qualification, so the scoreline is just as important as the points here.
Lautaro Martinez is trying to score for the fourth Champions League game in a row, starting again alongside Romelu Lukaku, as Alexis Sanchez is out until 2020.
Roberto Gagliardini and Kwadwo Asamoah join Sanchez and Danilo D’Ambrosio on the treatment table, but Stefano Sensi is available for a spot on the bench.
The Italian is not considered fit enough to start, so Matias Vecino gets the nod in midfield.
Antonio Candreva and Cristiano Biraghi are on the wings, with veteran Diego Godin in defence.
Borussia Dortmund are unbeaten at home this season in all competition, but have also not scored yet at the Signal Iduna Park in the Champions League, although their only game here was a 0-0 draw with Barcelona on September 17.
Marcel Schmelzer is still out of action and captain Marco Reus failed a last-minute fitness test, while Paco Alcacer is back on the bench following his lay-off.
Jadon Sancho, Julian Brandt and Thorgen Hazard fan out behind Mario Götze, as they return to the usual 4-2-3-1 shape after moving to three at the back at San Siro.
There are two surprises, as Nico Schulz takes the left-back slot from Raphael Guerreiro, whereas Julian Weigl plays in midfield rather than Thomas Delaney.
Borussia Dortmund:Bürki; Hakimi, Akanji, Hummels, Schulz; Witsel, Weigl; Sancho, Brandt, Hazard; Götze
Borussia Dortmund bench:Oelschlagel, Zagadou, Delaney, Dahoud, Alcacer, Guerreiro, Piszczek
Inter:Handanovic; Godin, De Vrij, Skriniar; Candreva, Vecino, Brozovic, Barella, Biraghi; Lautaro Martinez; R Lukaku
Inter bench:Padelli, Sensi, Politano, Lazaro, Borja Valero, Esposito, Bastoni
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