Inter have Lautaro Martinez, Romelu Lukaku, Stefano Sensi and Nicolò Barella in the starting XI away to struggling Lecce, who change system.
It kicks off at the Stadio Via del Mare at 14.00 GMT.
Antonio Conte needs to get back on track after a 1-1 home draw with Atalanta saw them lose the leadership of Serie A and Winter Champions crown to Juventus.
Lautaro Martinez was rested midweek for the Coppa Italia 4-1 win over Cagliari, but he returns to partner Romelu Lukaku.
Sensi and Barella are fit enough to start together after quite a while, but they are practically the only choices, because Roberto Gagliardini, Matias Vecino, Danilo D’Ambrosio and Kwadwo Asamoah are injured.
Ashley Young just arrived from Manchester United and didn’t make the trip down south to Lecce.
As for the hosts, Marco Calderoni, Diego Farias and Yevhen Shakhov are in the stands, with Zan Majer not 100 per cent fit.
Fabio Liverani’s side have lost four Serie A games on the trot, so transform to three at the back with Gianluca Lapadula, Khouma Babacar and Marco Mancosu upfront.
Lecce are without a single home victory this season, although they did hold Juventus 1-1 here.
Lecce:Gabriel; Rossettini, Lucioni, Dell’Orco; Rispoli, Deiola, Petriccione, Donati; Mancosu; Babacar, Lapadula
Inter: Handanovic; Godin, De Vrij, Skriniar; Candreva, Barella, Brozovic, Sensi, Biraghi; Lukaku, Lautaro Martinez
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