Lazio try to get back on track with Felipe Caicedo partnering Ciro Immobile and Manuel Lazzari facing his former club SPAL.
It kicks off at 14.00 UK time (13.00 GMT),follow all the action as it happens from today’s six Serie A games on the LIVEBLOG.
The Aquile had a strong start to the season, beating Sampdoria 3-0 and were unlucky only to draw 1-1 with Roma after rattling the woodwork four times in the Derby della Capitale.
Luiz Felipe, Bobby Adekanye and Jordan Lukaku are out injured, while Joaquin Correa is rested in favour of Caicedo ahead of the Europa League opener on Thursday.
Lazzari returns to the Stadio Paolo Mazza to face his former club, who he helped from Serie C to the top flight.
SPAL have struggled so far this term with back-to-back defeats against Atalanta and Bologna, although they were very close-run affairs.
In fact, the Spallini had been leading Atalanta 2-0 before the comeback and were only beaten by Bologna deep into stoppages.
Mohamed Fares is a long-term absentee, but Arkadiusz Reca starts after a loan move from Atalanta, supporting Federico Di Francesco and Andrea Petagna.
Alessandro Murgia was a Lazio youth product and takes on his former teammates.
It’s a difficult fixture, as Lazio lost here 1-0 last season, but in January 2018 the Aquile earned a spectacular 5-2 victory with Immobile scoring four goals.
SPAL:Berisha; Tomovic, Vicari, Cionek; D’Alessandro, Murgia, Missiroli, Kurtic, Reca; Di Francesco, Petagna
Lazio:Strakosha; Patric, Acerbi, Radu; Lazzari, Parolo, Leiva, Luis Alberto, Lulic; Immobile, Caicedo