Inter youngster Lucien Agoume could be in line for his first start with Sebastiano Esposito, as the Nerazzurri close 2019 against Genoa.
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Antonio Conte’s squad is at breaking point, particularly in midfield, with injuries decimating his options.
Marcelo Brozovic is suspended, leaving Conte with none of his first-choice midfielders available. Stefano Sensi may be fit enough for the bench, but isn’t expected to start.
Antonio Candreva, re-born as a right wing-back under Conte, could be shifted over to the middle, along with Borja Valero and Mattias Vecino in a makeshift midfield.
However another option could be to give 17-year-old Agoume his first start.
The Frenchman made his debut in the final minutes of last week’s game against Fiorentina, and such is the situation in midfield, Conte might feel obliged to test the youngster from the start.
Lautaro Martinez is also out through suspension, so Sebastiano Esposito or Matteo Politano could play alongside Romelu Lukaku.
Genoa meanwhile are without elder statesman Goran Pandev, who misses a reunion against his old club through suspension.
Coach Thiago Motta could implement a 3-5-1 system, with Colombian Kevin Agudelo playing in behind lone striker Andrea Pinamonti, formerly of Inter.
Christian Kouame, Lukas Lerager and Cristian Zapata all remain out through injury.
Inter (3-5-2): Handanovic; Godin, De Vrij, Skriniar; D’Ambrosio, Candreva, Borja Valero, Vecino, Biraghi; R Lukaku, Esposito
Genoa (3-5-1-1): Radu; Biraschi, Romero, Criscito; Ghiglione, Radovanovic, Schöne, Cassata, Pajac; Agudelo; Pinamonti
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